On October 6th 2016, Alfonso Benítez-Páez (IATA-CSIC, Spain) will attend the European OneHealth/EcoHealth Workshop organised by Biodiversity and Health, in Brussels, Belgium. This workshop aims to bring together people from different communities in science, policy and practice to exchange experience and views, and discuss opportunities and challenges for integration and practice. Here he will discuss MyNewGut and the application of the microbiomes influence on energy balance and brain development-function to tackle diet-related diseases and behaviours.
Abstract: "The MyNewGut Project, which receives funding from the European Union’s Seventh Framework Programme, will research the composite lifestyle factors that influence the human gut microbiota and its genome (microbiome) and their impact on diet-related disorders, such as obesity and the associated comorbidities. One of the specific objectives of the project is to progress in the identification of the consortium of bacteria and pathways involved in nutrient metabolism and, thereby, in energy balance in humans. The role of the microbiota in the breakdown of indigestible carbohydrates is the best characterized to date but controversy exists about the physiological consequences of their fermentation and the specific role of the generated products (e.g. short-chain fatty acids). Gut microbiota is also likely to participate in the catabolism of peptides and amino acids and in the utilization of ammonium for amino acid biosynthesis.
The gut microbiota could also participate indirectly in lipid metabolism by interfering with the enterohepatic circulation of bile acids and directly by utilizing dietary fat that escapes digestion as reflected in metagenomics studies. Nevertheless, the understanding of the role of the microbiota in protein and lipid metabolism and their physiological consequences is by far more limited. Moreover, in last years gut microbiota has been characterized to contribute to modulate the Central Nervous System through production of neurotransmitters that seems to pivotal a role in the Gut-Brain axis to attenuate stress and its physiological side-effects. To progress in the understanding of diet-gut microbiota interactions, we will develop a multidisciplinary research approach, using functional omics-technologies and systems biology, in well-controlled human trials. This information will be used to develop microbiome-based dietary recommendations and interventions to ultimately reduce the socioeconomic burden of diet-related disorders in the EU."
A poster from the workshop is shown above.